Tantárgy adatlapja
The course covers the following topics: Principles of signal transduction (classification of the receptors, main signaling routes, reversible protein phosphorylation). Protein domains in signal transduction. Signalling with cAMP (adenylyl cyclase, protein kinase A, CREB transcription factor). Signalling with phosphoinositide derivatives (phospholipase C, protein kinase C, PI 3-kinase, protein kinase B). Receptor protein tyrosine kinase signaling. Signalling through the insulin receptor, diabetes mellitus. Non-receptor tyrosine kinase signalling. Signal transduction to and from adhesion molecules (integrins). NF-kappaB signalling. TGFbeta signalling. The regulation of the cell cycle (oncogenes, tumor suppressor genes). The programmed cell death (the survival signal, mechanisms of apoptosis). Molecular basis of tumorigenesis.
