Tantárgy adatlapja

Description:

1. Intro into constraint-based modeling
2. Model reconstruction: manual and automated strategies
3. The biomass objective function
4. Linear optimization
5. Modeling genetic perturbations
6. Evaluating the accuracy of genome-scale models
7. Advanced modelling: incorporating enzyme kinetic and proteome constraints
8. Studying overflow metabolism by modelling resource allocation
9. Enzyme promiscuity and underground metabolism: Predicting evolutionary adaptations

10.  Uses of genome-scale modelling in biotechnology

     11. Uses of genome-scale modelling to study human health: modelling the gut microbiota

     12. Using metabolic models to predict personalized drug response

List of selected literature:

1_What is flux balance analysis?

https://www.nature.com/articles/nbt.1614

2_Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies

ass="cs73E18CB">https://www.nature.com/articles/s41467-022-28467-6

3_Network-level architecture and the evolutionary potential of underground metabolism

https://www.pnas.org/doi/full/10.1073/pnas.1406102111

4_Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine

https://www.nature.com/articles/s41587-022-01628-0

 

 

A tárgy az alábbi képzéseken vehető fel

Keresés

Képzés neve	Képzéskód	Képzési szint	Tagozat	Képzés nyelve	Félévszám	Felelős kar
Roska Tamás Műszaki és Természettudományi Doktori Iskola képzése	IDLI-AIMTX	Doktori képzés (PhD/DLA) (Nftv. 114 (2))	Levelező	angol	8 félév	ITK