Tantárgy adatlapja
The goal of this course is to demonstrate examples and highlight recent results of translational oncology. Basic concepts and advanced research topics in key directions of translational clinical research will be discussed, including:
oncogenesis (oncogenes and tumor suppressor genes)
angiogenesis
metastasis formation
clinical samples (origin and aim)
primary cell cultures and cell lines
tumor heterogeneity
2D cellular models (proliferation, migration)
3D cell-models (spheroids, matrices and invasion)
animal models (PDX, tumor progression and colonization models)
liquid biopsy and extracellular vesicles (principles and clinical applications)
Selested literature:
Beverly A. Teicher (ed): Tumor Models in Cancer Research (2011)
ESMO Handbook of Translational Research (2015)
Geoffrey M. Cooper: The Cell: A Molecular Approach (2019)
