Tantárgy adatlapja
Tárgy neve: A gyógyszer beviteli kutatások legújabb eredményei
Tárgy kódja: P_DO_0218
Óraszám: N: 6/0/0, L: 0/0/0
Kreditérték: 6
Az oktatás nyelve: angol
Követelmény típus: Gyakorlati jegy
Felelős kar: ITK
Felelős szervezeti egység: ITK Doktori és Habilitációs Iroda
Tárgyfelelős oktató:
Vidáné dr. Erdő Franciska
Tárgyleírás:
- S1.Anatomical and molecular properties of the blood-brain barrier 2.Anatomical/cellular properties of nasal drug delivery route 3.Anatomical features of dermal drug delivery route 4.Methodological opportunities for testing dermal drug delivery (in vitro, ex vivo, in vivo) 5.Microfluidic diffusion chambers 6.Drug formulation techniques to enhance dermal drug absorption 7.Physical methods to enhance dermal drug delivery 8.Tricks for overcoming the blood-brain barrier 9.Studying species differences in the skin 10.Opportunities to reduce the number of experimental animals in drug delivery studies 11.Testing dermal barrier permeability in healthy and diseased conditions. 12.Testing blood-brain barrier permeability in healthy and diseased conditions. Selected literature: Kocsis D, Klang V, Schweiger EM, Varga-Medveczky Z, Mihály A, Pongor C, Révész Z, Somogyi Z, Erdő F. Characterization and ex vivo evaluation of excised skin samples as substitutes for human dermal barrier in pharmaceutical and dermatological studies. Skin Res Technol. 2022 Jun 21. doi: 10.1111/srt.13165 Share Kocsis D, Horváth S, Kemény Á, Varga-Medveczky Z, Pongor C, Molnár R, Mihály A, Farkas D, Naszlady BM, Fülöp A, Horváth A, Rózsa B, Pintér E, Gyulai R, Erdő F. Drug Delivery through the Psoriatic Epidermal Barrier-A "Skin-On-A-Chip" Permeability Study and Ex Vivo Optical Imaging. Int J Mol Sci. 2022 Apr 11;23(8):4237. doi: 10.3390/ijms23084237 Ponmozhi J, Dhinakaran S, Varga-Medveczky Z, Fónagy K, Bors LA, Iván K, Erdő F. Development of Skin-On-A-Chip Platforms for Different Utilizations: Factors to Be Considered. Micromachines (Basel). 2021 Mar 10;12(3):294. doi: 10.3390/mi12030294. Lukács B, Bajza Á, Kocsis D, Csorba A, Antal I, Iván K, Laki AJ, Erdő F. Skin-on-a-Chip Device for Ex Vivo Monitoring of Transdermal Delivery of Drugs-Design, Fabrication, and Testing. Pharmaceutics. 2019 Sep 2;11(9):445. doi: 10.3390/pharmaceutics11090445. Luca Anna Bors and Franciska Erdő Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery, Sci. Pharm. 2019, 87(1), 6; https://doi.org/10.3390/scipharm87010006 Required competences: Analyzing and synthetizing ability to make short, informative presentations on recent scientific results on the field of drug delivery across the physiological barriers. Getting theoretical background knowledge on the field of physiological barriers and making and evaluating the drug delivery experiments.
